How neuronal activity leads to Alzheimer's protein cleavage
Amyloid precursor protein (APP), whose cleavage product, amyloid-b (Ab), builds up into fibrous plaques in the brains of Alzheimer's disease patients, jumps from one specialized membrane microdomain to...
View ArticleNew insights into how SARS pathogen infects host
(PhysOrg.com) -- When Severe Acute Respiratory Syndrome (SARS) first appeared in 2003, international cooperation helped contain the virulent coronavirus, which caused respiratory illness in more than...
View ArticleNewly found DNA catalysts cleave DNA with water molecule
Better tools for manipulating DNA in the laboratory may soon be possible with newly discovered deoxyribozymes (catalytic DNA) capable of cleaving single-stranded DNA, researchers at the University of...
View ArticleHow proteins talk to each other: Caspase-3 cleaves in unforeseen ways
Investigators at Burnham Institute for Medical Research have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced...
View ArticleLive imaging puts new light on stem cell division
(PhysOrg.com) -- A long-held assumption about asymmetrical division of stem cells has cracked. Researchers at the University of Oregon report that the mitotic spindle does not act alone -- that...
View ArticleOvastacin cuts off sperm binding
A study in The Journal of Cell Biology describes how a secreted enzyme helps egg cells avoid being fertilized by more than one sperm.
View ArticleWe need to talk: How cells communicate to activate notch
During formation of multi-cellular organisms, cells need to talk to each other to make critical decisions as to what kind of cell to become, as well as when and where to become that cell type. The...
View ArticleNew technique reveals cross-talk between two essential cellular processes
Scientists at The Scripps Research Institute have simultaneously mapped two of the most important types of protein-modification in cells, revealing their extensive cooperation during an essential...
View ArticleResearchers clarify catalysis mechanism of cell growth protein Ras
Proteins accelerate certain chemical reactions in cells by several orders of magnitude. The molecular mechanism by which the Ras protein accelerates the cleavage of the molecule GTP and thus slows cell...
View ArticleWhen boron butts in: Bridging N–N ligand borylation in group 4 metallocene...
For nature and chemists alike, making atmospheric nitrogen available for the formation of more complex nitrogen compounds is both essential and difficult. In the European Journal of Inorganic...
View ArticleCutting cancer to pieces: New research on bleomycin
A variety of cancers are treated with the anti-tumor agent bleomycin, though its disease-fighting properties remain poorly understood. In a new study, lead author Basab Roy—a researcher at Arizona...
View ArticleRare byproduct of marine bacteria kills cancer cells by snipping their DNA
(Phys.org) —Yale University researchers have determined how a scarce molecule produced by marine bacteria can kill cancer cells, paving the way for the development of new, low-dose chemotherapies.
View ArticleCell division, minus the cells
(Phys.org) —The process of cell division is central to life. The last stage, when two daughter cells split from each other, has fascinated scientists since the dawn of cell biology in the Victorian...
View ArticleGroup dynamics, not star proteins, drive mechanics of crucial cell process
Like a surgeon separating conjoined twins, cells have to be careful to get everything just right when they divide in two. Otherwise, the resulting daughter cells could be hobbled, particularly if they...
View ArticleSodium selective DNAzyme sensor
(Phys.org)—Sodium ions are key regulators in cellular processes. The fluids in cells, whether it is water, blood plasma, or nutrients, are regulated by the sodium concentration in cells. If scientists...
View ArticleHow Microprocessor precisely initiates miRNA production
A scientific group from the Center for RNA Research within the Institute for Basic Science (IBS) and School of Biological Sciences in Seoul National University has reported an insightful molecular...
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